Chronic inhalation toxicity study of 1,2-dichloroethane (EDC) in rats treated with disulfiram or ethanol. Final chronic report, part I, volume 1 of 2, toxicology and pathology.
Cholakis-JM; Steele-DH; Peterson-SD; Hagensen-JH; Liu-GK; Chatham-AT; McCann-SA; Smith-KJ; Williamson-DJ; Hong-HD; Templeman-CC; Kovatch-RM
Midwest Research Institute, Kansas City, Missouri 1985 Sep; :1-379
Sprague-Dawley-rats were used to study the effects of inhaled 1,2- dichloroethane (107062) (EDC) in the presence and absence of disulfiram (97778) in the diet, and with or without ethanol (64175) in the drinking water. Rats were exposed to EDC at 50 parts per million for 7 hours per day, 5 days per week for 24 months. All animals receiving disulfiram showed lower body weight gains, but demonstrated no other changes regarding toxicity, survival, or food intake. An increased incidence of liver masses was noted in male and female rats receiving EDC and disulfiram. This finding is in agreement with other findings concerning the synergistic effects of haloethanes and disulfiram. The pharmacological agent greatly enhanced the carcinogenicity of the carcinogen. The high incidence of intrahepatic bile duct cholangiomas in both male and female rats and neoplastic nodules in male rats indicate that the combined EDC/disulfiram treatment must be considered carcinogenic to the liver. Male rats also showed significantly increased interstitial cell tumors of the testes and fibromas of the subcutis. Female rats demonstrated increased incidence of adenocarcinomas of the mammary gland. Kidney lesions were more frequent in the male EDC treatment group.
NIOSH-Contract; Contract-200-82-2508; Solvents; Inhalants; Pulmonary-system-disorders; Laboratory-animals; Cancer-rates; Liver-disorders
107-06-2; 97-77-8; 64-17-5
Final Contract Report
NTIS Accession No.
Asthma and Chronic Obstructive Pulmonary Disease; Disease and Injury; Pulmonary-system-disorders
Midwest Research Institute, Kansas City, Missouri