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Toxicity data for establishing "Immediately Dangerous to Life or Health" (IDLH) values.
Price NH; Allen SD; Daniels AU; Yates WG
University of Utah Research Institute, Salt Lake City, Utah, UBTL Division, Report TR 1510-005 1978 Aug; :1-247
Rats and guinea pigs (ten of each) were individually exposed to 30 minute inhalation tests using industrial chemicals to develop Immediately Dangerous to Life or Health (IDLH) Values. The no effect (NE) level concentration was defined as that concentration producing none of the following treatment related effects in any animal: death, irreversible pathological lesions, or impaired escape ability during the exposure. The minimal effect (ME) level was defined as that concentration producing one or more of the treatment related effects in one or two animals regardless of sex or species. The frank effect (FE) level was defined as that concentration producing one or more of the treatment related effects in three or more animals regardless of sex or species. Findings for the chemicals tested were as follows: 1,2,3-trichloropropane (96184), NE at 799 parts per million (ppm) and FE at 2,080ppm; monochlorobenzene (108907), NE at 2,990 and FE at 5,850ppm; 1,1,2,2- tetrachloroethane (79345), NE at 576ppm and FE at 5,050ppm; 3- chloropropene (107051), NE at 1,300 and 11,800ppm; N,N- dimethylaniline (121697), NE at 194 and 953ppm; 1,1,2,2- tetrabromoethane (79276), NE at 19.9 and 91.1ppm; dimethoxymethane (109875), NE at 2,810 and 8,540ppm; and phenol (108952), NE at 187ppm and FE at 540ppm.
NIOSH-Contract; Contract-210-76-0143; Laboratory-animals; Inhalants; Solvents; Organo-chlorine-compounds; Chemical-industry-workers;
96-18-4; 108-90-7; 79-34-5; 107-05-1; 121-69-7; 79-27-6; 109-87-5; 108-95-2
NTIS Accession No.
University of Utah Research Institute, Salt Lake City, Utah, UBTL Division, Report TR 1510-005
Page last reviewed: March 11, 2019
Content source: National Institute for Occupational Safety and Health Education and Information Division