Epidemiology of malignant melanoma: pigmentary traits, ultraviolet radiation, and the identification of high-risk populations.
Dubin-N; Moseson-M; Pasternack-BS
Epidemiology of Malignant Melanoma. Gallagher RP, ed., New York: Springer-Verlag, 1986 Jan; :56-75
A case control study of malignant melanoma was conducted. The cohort consisted of 1103 white cases of malignant melanoma, 566 females. The comparisons consisted of 585 individuals, 320 females, at a skin clinic. The mean age of the cohort was 52.1 years and the comparisons 43.0 years. The subjects were interviewed at New York University Medical Center. The interviews included a thorough epidemiologic questionnaire regarding known incidence risk factors for malignant melanoma. All patients were given a physical examination during which the numbers of moles and freckles were counted. Epidemiological risk factors were evaluated by calculating odds ratios. Among the skin characteristics examined, freckling (particularly heavy freckling), number of moles, and tendency to burn were significantly associated with the risk of melanoma. The ability to tan was inversely related to risk. Skin color was not as strongly associated with risk as the other factors. Having red hair or blue eyes was associated with a doubled risk, and having black hair was associated with a 0.333 risk. Having a history of solar keratosis was a strong risk determinant. A mostly outdoor work experience was positively associated with an increased risk of melanoma. A decreased risk was associated with participation in mixed indoor and outdoor activities. No significant trends of increasing melanoma risk with average hours of sun exposure were seen. Melanoma in a first degree relative was associated with a statistically insignificant increased odds ratio. The authors conclude that heavy freckling, a history of solar keratosis, and inability to suntan are apparent significant risk factors for malignant melanoma.
NIOSH-Grant; Epidemiology; Case-studies; Skin-cancer; Disease-incidence; Skin-lesions; Malignant-neoplasms; Malignancy; Risk-factors; Risk-analysis
Epidemiology of Malignant Melanoma
Environmental Medicine New York University 550 First Avenue New York, NY 10016