Review of exposure and pathology data for seven cases reported as soft tissue sarcoma among persons occupationally exposed to dioxin-contaminated herbicides.
Fingerhut-MA; Halperin-WE; Honchar-PA; Smith-AB; Groth-DH; Russel-WO
Public Health Risks of the Dioxins (proceedings of a symposium held on October 19 to 20, 1983, New York City, New York) 1984:187-204
Prompted by earlier reports indicative of a strong association between the occurrence of soft tissue sarcoma and exposure to dioxins, the death certificates and pathology records of seven chemical workers affected by soft tissue sarcoma were reviewed. Four of the workers had been employed in the production of trichlorophenol (25167822) (TCP) or 2,4,5-trichlorophenoxyacetic- acid (93765) (2,4,5-T), two herbicides known to be contaminated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (1746016). A review of the slides used to establish their initial pathological diagnosis revealed that only two of them actually had soft tissue sarcoma; the other two had poorly differentiated or clear cell carcinomas. Histopathological review of the three other cases, presented in the literature as case reports, confirmed the initial diagnosis of soft tissue sarcoma, but the available evidence failed to reveal employment in the production of TCP or 2,4,5-T, although one of the cases had an occupational history of brief exposure to pentachlorophenol (87865), known to be contaminated with some other dioxin isomers. The authors conclude that death certificates and pathology records are not reliable sources for the identification of cases of soft tissue sarcoma and recommend large scale studies to determine the validity of the association between exposure to dioxins and the occurrence of the neoplasm.
Occupational-exposure; Agricultural-chemicals; Carcinogenesis; Chlorophenoxy-herbicides; Exposure-levels; Histopathology; Diagnostic-techniques; Humans
25167-82-2; 93-76-5; 1746-01-6; 87-86-5
Public Health Risks of the Dioxins (proceedings of a symposium held on October 19 to 20, 1983, New York City, New York)