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Fibrogenic Effects and Chemical Characterization of Coal and Mineral Slags Used as Sand Substitutes.

Stettler-LE; Groth-DH; Platek-SF; Donaldson-HM
Health Issues Related to Metal and Nonmetallic Mining 1983:135-160
Studies were carried out to investigate the biological activity of coal and other mineral slags used in abrasive blasting. Analysis of 18 slag samples, using absorption spectrophotometry and proton induced X-ray fluorescence, revealed the presence of potentially hazardous elements including beryllium (7440417), chromium (7440473), nickel (7440020) and arsenic (7440382), all of which have been classified by NIOSH as suspect carcinogens; coal slags had the lowest concentrations of such elements. The potential fibrogenic effect of coal and copper slags was assessed in male Sprague-Dawley- rats treated intratracheally with 20 milligrams of test material. Histopathological examination of lung tissue obtained from the treated animals revealed the presence of granulomas in all animals; lung fibrosis was recorded in the coal slag treated group, but not in the animals treated with copper slag. The fibrogenic and carcinogenic activity of two copper slags and one nickel slag were tested in male Fischer-344-rats instilled intratracheally with 20 milligrams of the test materials. Twelve months after treatment, histopathological evaluation revealed slight lung reactions but no interstitial fibrosis or granuloma in the lungs of the rats treated with the nickel slag. The animals treated with the copper slags also showed various degrees of alveolar wall thickening and interstitial fibrosis. There was no evidence of granuloma in the lungs of the animals treated with the nickel or copper slags.
Occupational-exposure; Dust-exposure; Dust-inhalation; Fibrogenesis; Coal-dust; Mineral-dusts; Dust-analysis; Analytical-methods; Laboratory-animals;
7440-41-7; 7440-47-3; 7440-02-0; 7440-38-2;
Publication Date
Wagner-WL; Rom-WN; Merchant-JA;
Fiscal Year
Source Name
Health Issues Related to Metal and Nonmetallic Mining
Page last reviewed: March 11, 2019
Content source: National Institute for Occupational Safety and Health Education and Information Division