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Tissue distribution of 14C-labeled ethylene dibromide in the guinea pig.
Res Commun Chem Pathol Pharmacol 1976 Feb; 13(2):251-258
Male Hartley-guinea-pigs were exposed to ethylene-dibromide (EDB) (106934) as a single intraperitoneal injection of 30 milligrams/kilogram (mg/kg) body weight in order to determine EDB tissue distribution. The animals were sacrificed at 4, 8, 12, 24, 48, or 72 hours following exposure. The kidneys, liver and adrenal glands recorded the highest levels of contamination. Kidneys recorded 286.64, 236.52, 247.79, 73.45, 14.66, and 10.47 micrograms EDB/gram (microg/g) of tissue at 4, 8, 12, 24, 48, and 72 hours, respectively. Liver concentrations for the same time periods were 129.03, 104.91, 78.39, 38.07, 16.20, and 15.58 microg/g. Adrenal gland concentrations were 60.73, 60.82, 25.56, 28.63, 13.24, and 10.43microg/g. Sixty-six percent of the administered dose was excreted through the urinary tract. Excretion in the feces was insignificant. About 10 to 12 percent of the administered dose may have been excreted in the exhaled air. The pattern of EDB distribution in the tissues as determined in this study is completely consistent with earlier studies of the pathologic changes brought about through exposure to this compound. The authors conclude that since inhalation appears to be the most likely route for human exposure both occupationally and environmentally, the carcinogenic potential of EDB should be assessed by utilizing the inhalation route.
Fumigants; Grain-dusts; Brominated-hydrocarbons; Inhalants; Kidney-damage; Liver-damage; NIOSH-Author
Issue of Publication
Research Communications in Chemical Pathology and Pharmacology
Page last reviewed: September 2, 2020
Content source: National Institute for Occupational Safety and Health Education and Information Division