Carcinogenic effects of antimony trioxide and antimony ore concentrate in rats.
Groth-DH; Stettler-LE; Burg-JR; Busey-WM; Grant-GC; Wong-L
J Toxicol Environ Health 1986; 18(4):607-626
Approximately 450 male and 450 female Wistar derived albino rats were used to study the chronic effects of the inhalation of antimony- trioxide (7790445) (Sb2O3) and antimony (7440360) (Sb) ore concentrate. The incidence of lung neoplasms was 19/59, or 32 percent, for those animals examined after 53 weeks of the study. Sb- ore induced the same effect at about the same incidence. These findings support observations of an increased incidence of lung cancer in workers exposed during the refining of Sb-ore in the production of Sb2O3. Female rats were more susceptible to the induction of lung cancer by both agents. Tissues and blood of female rats contained higher concentrations of arsenic than the males. The lung concentration of arsenic was higher in males than females exposed to Sb2O3. Female rats had a higher incidence of pituitary tumors than males. Even though the Sb-ore contained much more arsenic than the Sb2O3, rats exposed to Sb2O3 carried 5 to 6 times as much arsenic in their lungs. The authors suggest this may have been due to the solubility of the arsenic in Sb-ore. Studies of worker exposure indicate that workers are exposed to levels quite near to those used in this study. The authors conclude that antimony compounds are carcinogenic and mutagenic.
Laboratory-animals; Carcinogenesis; Mutagenesis; Smelters; Smelting; Lung-cancer; Lung-disorders; Lung-irritants; NIOSH-Author; NIOSH-Publication; Contract-210-77-0156; NIOSH-Contract
Journal of Toxicology and Environmental Health
Midwest Research Institute, Kansas City, Missouri