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Health hazard evaluation report: HETA-84-117-1696, Martin Marietta Michoud Operations, New Orleans, Louisiana.
Cincinnati, OH: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, HETA 84-117-1696, 1986 May; :1-19
Workers at the Martin Marietta Michoud Operations Facility (SIC- 3769), New Orleans, Louisiana requested an evaluation of asthma and liver function test abnormalities among workers in the Thermal Protection System (TPS) insulation areas with potential exposures to diphenylmethane-diisocyanate (101688) (MDI) and solvents. Three cases of probable MDI induced asthma were identified. There was no detectable group decline in one second forced expiratory volume associated with MDI exposure. In general, environmental levels of MDI in company records were below 25ppm. Respiratory protection was worn by operators and sprayers where MDI was present. In the final assembly area 9 of 103 workers had abnormal serum liver enzyme concentrations. The authors conclude that it is probable that some employees developed asthma as a result of exposure to MDI. Recommendations include informing workers of possible health hazards, clearly indicating the 25 foot hazard radius to be avoided during processes using MDI, reducing the 20 parts per billion permissible exposure limit ceiling for MDI currently in use, transfer workers who have isocyanate provoked asthma to other areas of the facility, carefully investigating any cases of job related illness for possible additional cases, and developing and implementing a monitoring strategy.
NIOSH-Author; HETA-84-117-1696; NIOSH-Health-Hazard-Evaluation; NIOSH-Technical-Assistance-Report; Region-6; Pulmonary-system-disorders; Respiratory-irritants; Lung-disorders; Organic-solvents; Isocyanates; Hepatotoxicity; Liver-damage; Enzyme-activity; Hazard-Confirmed; Author Keywords: Guided Missile and Space Vehicle Parts and Auxiliary Equipment, Not Elsewhere Classified; Diphenyimethane Diisocyanate; Isocyanates; Asthma; Hepatotoxcity
Field Studies; Hazard Evaluation and Technical Assistance
NTIS Accession No.
National Institute for Occupational Safety and Health
Page last reviewed: April 12, 2019
Content source: National Institute for Occupational Safety and Health Education and Information Division