An investigation of the modulation of viral induced enzyme activity in the liver microsomes of mice after exposure via inhalation to coal dust (CD) and diesel exhaust (DE) particulates was conducted by examining two metabolic systems: detoxication through cytochrome-P- 450 (P-450); and resistance to infection through interferon (IFN). White female mice (Swiss-CD1) were exposed using an inhalation chamber for 7 hours per day, 5 days per week to filtered air (FA), CD, or DE. Total particulate levels were 2 milligrams per cubic meter (mg/m3) for DE exposures, and 5mg/m3 for CD exposures. Respirable particulates of less than or equal to 7 micrometers were maintained at 2mg/m3 in both cases. Mice were inoculated with influenza-virus within 24 hours after exposure and during infection, liver microsome samples were obtained and the following enzyme activities were measured: 7-ethoxycoumarin-deethylase (7ECdeEt-ase); NADPH-c-reductase (NADPH-c-red-ase); ethylmorphine-demethylase (EMdeMe-ase). Infection by influenza-virus affected the specific activities of 7ECdeEt-ase and NADPH-c-red-ase as noted by an increased value for both enzymes on day four. Changes in microsomal liver content over the 8 day interval were not observed. Exposure to DE or CD did not result in significant changes in the decreased 7ECdeEt-ase activity observed in control mice (days one to three). The virus induced temporal pattern for EMdeMe-ase in exposed mice was altered. The authors suggested that a relationship exists between P-450 enzyme activity and IFN induction, at least in mice.
Links with this icon indicate that you are leaving the CDC website.
The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website.
Linking to a non-federal website does not constitute an endorsement by CDC or any of its employees of the sponsors or the information and products presented on the website.
You will be subject to the destination website's privacy policy when you follow the link.
CDC is not responsible for Section 508 compliance (accessibility) on other federal or private website.
For more information on CDC's web notification policies, see Website Disclaimers.
CDC.gov Privacy Settings
We take your privacy seriously. You can review and change the way we collect information below.
These cookies allow us to count visits and traffic sources so we can measure and improve the performance of our site. They help us to know which pages are the most and least popular and see how visitors move around the site. All information these cookies collect is aggregated and therefore anonymous. If you do not allow these cookies we will not know when you have visited our site, and will not be able to monitor its performance.
Cookies used to make website functionality more relevant to you. These cookies perform functions like remembering presentation options or choices and, in some cases, delivery of web content that based on self-identified area of interests.
Cookies used to track the effectiveness of CDC public health campaigns through clickthrough data.
Cookies used to enable you to share pages and content that you find interesting on CDC.gov through third party social networking and other websites. These cookies may also be used for advertising purposes by these third parties.
Thank you for taking the time to confirm your preferences. If you need to go back and make any changes, you can always do so by going to our Privacy Policy page.