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Health hazard evaluation report: HETA-81-385-1659, Texaco Chemical Company, Port Neches, Texas.
Cincinnati, OH: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, HETA 81-385-1659, 1986 Feb; :1-17
Following a request made by the Oil, Chemical and Atomic Workers Union, genotoxicity associated with occupational exposures to ethylene-oxide (75218) at the Texaco Chemical Company (SIC-2810), Port Neches, Texas, was evaluated. Blood and industrial hygiene samples were collected. The annual mean exposure to ethylene-oxide in the production departments had been 1.73 parts per million (ppm) or less during the period from 1978 through 1982 with short-term peak exposures over 100ppm. Analyses of the chromosomal aberrations (CA) and sister chromatid exchange (SCE) data suggest that the exposures appear to produce marginally significant increases in the group mean SCE frequency per chromosome per cell in nonsmokers compared to control nonsmokers. The author concludes that these exposures are not associated with an overwhelming increase in genotoxicity effect. Significant elevations observed in both the group mean SCE frequency per chromosome per cell and in group mean transformed CA frequency of lab workers compared to those frequencies observed in referents can not be attributed solely to ethylene-oxide due to the complex nature of this working environment. As a potential occupational carcinogen, exposure to ethylene oxide is to be reduced to the lowest extent possible.
NIOSH-Publication; NIOSH-Health-Hazard-Evaluation; HETA-81-385-1659; Carcinogens; Mutagens; Ethylenes; Oxides; Chromosome-disorders; Chemical-manufacturing-industry; Genetic-disorders; Region-6; Hazard-Unconfirmed; NIOSH-Technical-Assistance-Report; Author Keywords: Chemical Manufacturing; ethylene oxide; chromosomal aberrations; sister chromatid exchange; genotoxicity; laboratory workers; chemical workers
Field Studies; Hazard Evaluation and Technical Assistance
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National Institute for Occupational Safety and Health
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Content source: National Institute for Occupational Safety and Health Education and Information Division