An epidemiological study was conducted on the presence of antinuclear and rheumatoid factors in blood sera of coal (8002059) miners. The cohort consisted of 236 working miners from 31 mines in Pennsylvania and West Virginia. All miners underwent a limited medical examination that consisted of posteroanterior and lateral chest films, and spirometry. A questionnaire was given and data on incidences of bronchitis and respiratory symptoms was obtained. Blood serum was sampled from all subjects and rheumatoid factor tests were carried out. Antinuclear antibody determinations were performed by immunofluorescence. One hundred and fifty six subjects with occupational pneumoconiosis were interviewed and anthropometric data was analyzed. About 4 percent of miners had a rheumatoid factor titer of 1/160 or greater and showed radiographic evidence of pneumoconiosis. Other miners had rheumatoid factor titers in the range of 1/320 to 1/40. Thirty four percent of coal miners with pneumoconiosis showed antinuclear antibodies whereas only 2 miners with normal radiographs had antibodies. No significant difference between simple and complicated pneumoconiosis was noted with respect to antinuclear antibodies. Bituminous miners had a significantly lower antibody titer in relation to anthracite miners. The authors conclude that unknown chemical agents present in anthracite and certain bituminous coal mine dusts may be responsible for enhanced antibody formation.
We take your privacy seriously. You can review and change the way we collect information below.
These cookies allow us to count visits and traffic sources so we can measure and improve the performance of our site. They help us to know which pages are the most and least popular and see how visitors move around the site. All information these cookies collect is aggregated and therefore anonymous. If you do not allow these cookies we will not know when you have visited our site, and will not be able to monitor its performance.
Cookies used to make website functionality more relevant to you. These cookies perform functions like remembering presentation options or choices and, in some cases, delivery of web content that based on self-identified area of interests.
Cookies used to track the effectiveness of CDC public health campaigns through clickthrough data.
Cookies used to enable you to share pages and content that you find interesting on CDC.gov through third party social networking and other websites. These cookies may also be used for advertising purposes by these third parties.