NIOSHTIC-2 Publications Search

Methyl chloride and diazepam effects on performance.

Authors
Putz-Anderson V; Setzer JV; Croxton JS; Phipps FC
Source
Scand J Work Environ Health 1981 Mar; 7(1):8-13
NIOSHTIC No.
00158236
Abstract
Behavioral effects from ingestion of diazepam (439145) and inhalation of methyl-chloride (74873) were investigated in humans. A total of 17 female and 39 male subjects ranging in age from 18 to 32, with a mean of 22 years, participated in the study. They were exposed to methyl-chloride at 0, 100, and 200 parts per million (ppm) for 3 hours and to diazepam at 0 and 10 milligrams. Each participant was tested in an environmental room for alertness during 5 hours of testing. Three behavioral tests used were visual vigilance, dual task, and time discrimination. Breath and blood samples were taken at various intervals and tested. Degree of impairment on behavioral tests was expressed as the percentage of change between pretreatment and subsequent testing period during exposure. Large interindividual differences in breath and blood levels were found for methyl-chloride. The control group showed an average decline of 27.3 percent in performance between pre control and control test periods. Diazepam treatment showed an average 10.1 percent impairment in task performance. Treatment of 200ppm methyl- chloride showed an average of 4 percent performance impairment and combined diazepam and methyl-chloride treatment showed an average impairment of 13.5 percent. Through univariate analysis, only threshold performance of vigilance test scores and response block measures of time discrimination were sensitive indicators of methyl- chloride impairment. In contrast, diazepam had a significant effect on all test indices except the response block measures of time discrimination. The authors conclude that potential hazards from combined central nervous system depressants can affect alertness and coordination of exposed workers.
Keywords
NIOSH-Author; Pulmonary-function; Toxic-effects; Physiological-response; Chemical-properties; Lethal-concentrations; Respiratory-hypersensitivity; Biological-effects; Exposure-levels; Behavioral-testing; Lung-function; Author Keywords: alertness; behavioral test; diazepam; toxicology
Contact
Dr V Putz-Anderson, Robert A Taft Laboratories, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, Cincinnati, OH 45226, USA
CODEN
SWEHDO
CAS No.
439-14-5; 74-87-3
Publication Date
19810301
Document Type
Journal Article
Fiscal Year
1981
Issue of Publication
1
ISSN
0355-3140
NIOSH Division
DBBS
Source Name
Scandinavian Journal of Work, Environment & Health
State
OH
Page last reviewed: June 28, 2019
Content source: National Institute for Occupational Safety and Health Education and Information Division