Carcinogenic Potential Of Foundry Pyrolysis Effluents.
Moorman-WJ; Palmer-WG; Garner-FM; Mulligan-LT
The carcinogenic potential of foundry pyrolysis effluents was studied in hamsters. Emissions from molds composed of furan (110009), green sand with sea coal, urethane (51796), and phenol (108952) formaldehyde (50000) resins in shell molds were collected and analyzed. The effluents were administered to Syrian-Golden- hamsters by intratracheal instillation for 18 weeks. The dose was 10 milligrams (mg) for green sand, shells, and furan. The urethane mold effluent was administered at a dose of 5mg. Positive controls were given benzo(a)pyrene (50328) (BaP) plus ferric-oxide (1309371). The animals were observed for tumor development. Survival was recorded. Phenanthrene (85018) was found in all four mold effluent samples. Benzo(a)anthracene (56553) was found in all samples except the furan mold. Measurable quantities of BaP were found only in the shell and green sand samples. Naphthalene (91203) was found only in the urethane sample. Phenol was found in all samples and 4- nitrophenol (100027) was found in all samples except the green sand sample. Male hamsters generally out lived females, the 98 percent termination point occurring at 117 and 103 weeks, respectively. No treatment induced respiratory system tumors occurred except in the positive controls. A fairly high incidence of adrenal cortical tumors was observed. Follicular cell tumors of the thyroid were also found. A low incidence of tumors of the gastrointestinal, urogenital, and lymphatic/hematopoietic systems occurred. The authors note that the findings are preliminary in nature. The low tumor incidence may be due to only small amounts of the carcinogenic fractions of the effluents being administered due to their high acute toxicity.
Cancer; Laboratory-animals; Lung-irritants; Chemical-composition; Emission-sources; Dose-response; Tumorigenesis; Respiratory-irritants; Carcinogens; Industrial-emissions;
110-00-9; 51-79-6; 108-95-2; 50-00-0; 50-32-8; 1309-37-1; 85-01-8; 56-55-3; 91-20-3; 100-02-7;
Proceedings of the Third NCI/EPA/NIOSH Collaborative Workshop: Progress on Joint Environmental and Occupational Cancer Studies