Mortality And Industrial Hygiene Study Of Styrene-Butadiene Rubber Workers.
Meinhardt-TJ; Lemen-RA; Crandall-MS; Young-RJ
A study of mortality in styrene (100425) butadiene (106990) rubber workers was conducted. The cohort consisted of 2,756 white male workers who were employed at least 6 months since January 1, 1943 or January 1, 1950 at two styrene/butadiene rubber factories (SIC-2822) in Texas. The vital status of the cohort as of March 31, 1976 was determined. Death certificates were examined. Industrial hygiene sampling for styrene, butadiene, and benzene (71432) was performed. Mean concentrations of styrene at the two facilities were 0.94 and 1.99 parts per million (ppm). The corresponding mean concentrations of butadiene were 1.24 and 13.50ppm. Benzene concentrations measured at one facility ranged from 0.08 to 0.14ppm. Overall mortality and cause/specific mortality were not significantly elevated at either facility. The records of the subjects identified with leukemia were reviewed. Most of these subjects had started work before the end of December, 1945. When the subcategories of lymphatic and hematopoietic tissue malignancies were analyzed, a statistically significant excess of mortality from leukemia and aleukemia was detected. The authors note that continued analysis of the mortality occurring in styrene/butadiene rubber workers will probably never provide definitive answers about the health effects associated with styrene or butadiene because of the concomitant exposure to many other chemicals. It cannot be determined at the present time whether a real leukomogenic risk is associated with styrene/butadiene rubber production.
Workplace-studies; Health-hazards; Epidemiology; Occupational-exposure; Analytical-methods; Mortality-rates; Industrial-environment; Quantitative-analysis; Exposure-levels; Occupational-hazards;
100-42-5; 106-99-0; 71-43-2;
Proceedings of the Third NCI/EPA/NIOSH Collaborative Workshop: Progress on Joint Environmental and Occupational Cancer Studies