Cytogenetic Study Of Workers Exposed To Ethylene Oxide: Analysis Of The Chromosomal Aberration Data And Overall Conclusions From The Analyses Of Sister Chromatid Exchanges And Chromosomal Aberrations.
Meinhardt-T; Carrano-A; Moore-D; Ashworth-L; Marlow-D
NIOSH 1985 Dec:62 pages
A survey of the cytogenetic effects of exposure to ethylene-oxide (75218) was conducted. The cohort consisted of 43 workers in ethylene-oxide production units and 27 workers in a quality assurance laboratory who were exposed to ethylene-oxide and other chemicals. The comparisons consisted of 41 individuals having no exposure to chemicals. Circulating lymphocytes were isolated and assayed for chromosomal aberrations. Ethylene-oxide exposures in the production unit and quality assurance laboratory were measured. Median ethylene-oxide exposures ranged from 0.14 to 10.9 parts per million (ppm) in the laboratory and 0.19 to 1.0ppm in the production unit over a 5 year period. No significant increase in the incidence of chromosomal aberrations occurred in the production unit workers. Increases in the incidence of chromatid deletions and exchanges, total chromatid aberrations, percent of abnormal cells and total aberrations per cell occurred in the laboratory workers. The authors suggest that working in ethylene-oxide production units does not cause a statistically significant increase in chromosomal aberrations. Work in the quality assurance laboratory is associated with genotoxic effects; however, these cannot be attributed solely to ethylene-oxide due to the complex nature of the working environment.
NIOSH-Author; Bioassays; Genetic-factors; Occupational-exposure; Trace-analysis; Laboratory-workers; Laboratory-techniques; Workplace-studies; Cytology; Exposure-levels;
NTIS Accession No.
Division of Surveillance, Hazard Evaluations and Field Studies, NIOSH, U.S. Department of Health and Human Services, Cincinnati, Ohio, 62 pages, 46 references