Retrospective Cohort Mortality Study Of Dry Cleaner Workers Using Perchloroethylene.
NIOSH 1985 Dec:45 pages
A mortality study of workers in the dry cleaning industry (SIC-7216) was conducted. The purpose of the study was to evaluate the carcinogenic potential of perchloroethylene (127184) (PCE), a dry cleaning solvent. The cohort consisted of 1,690 workers employed for at least 1 year before 1960 in dry cleaning shops. The vital status of the cohort was determined as of December 31, 1982. Person years at risk (PYAR) were calculated for each worker. The cohort contributed 42,267 PYAR to the analysis. A total of 493 deaths occurred, versus 575.5 expected. A total of 137 deaths occurred among 615 workers employed in shops where PCE was the major solvent. Overall cancer mortality was 142, versus 122.9 expected. No deaths due to liver cancer were observed. Urinary tract cancer was the only site specific cancer having a significant increase of deaths; 12 occurred versus 4.7 expected. In the sub cohort exposed primarily to PCE only, only 1 urinary tract cancer death occurred, versus 1.3 expected. The authors note that the excess risk for urinary tract cancer may be due to chance. The confounding exposures to petroleum solvents complicate any conclusions regarding the association between PCE exposure and urinary tract cancer.
NIOSH-Author; Toxic-effects; Carcinogenesis; Workplace-studies; Occupational-exposure; Epidemiology; Human-studies; Mortality-rates;
Division of Surveillance, Hazard Evaluations and Field Studies, NIOSH, U.S. Department of Health and Human Services, Cincinnati, Ohio, 45 pages, 22 references