Glucagon induced renal vasodilation changes in zinc (7440666) excretion were compared to acetylcholine (51843) induced alterations in dogs. Male dogs, anesthetized with 30 milligrams/kilogram (mg/kg) pentobarbital, were infused with 5 or 50 nanograms (ng)/kg/minute glucagon in saline, or saline alone. Sequential 15 minute urine collections were made and arterial blood samples were taken. Effects of 25 micrograms/minute acetylcholine infused into the renal artery on zinc excretion and renal function were compared. In three other dogs, ultrafilterable plasma zinc concentrations were evaluated using zinc-65, intravenously infused 2 hours before infusion of 50ng/kg/minute glucagon. Radioactivity in samples of blood, plasma, filtrate, and urine was counted. Zinc excretion in control animals was relatively constant. The lower dose of glucagon increased zinc excretion slightly in all four animals, with a return to control concentrations during the recovery hour in 75 percent. However, 50ng/kg/minute glucagon increased zinc excretion as much as 50 percent, with a return to control concentrations within 1 hour in all but one animal. Plasma zinc tended to decrease in the control and both treatment groups, possibly in relation to surgical trauma. Low dose glucagon tended not to increase urine flow and sodium excretion significantly; however, 50ng/kg/minute glucagon increased mean urine flow 0.15 milliliter (ml)/minute and sodium excretion 35 microequivalents/minute at peak values, while significantly increasing both glomerular filtration rate and effective renal plasma flow. Acetylcholine did not significantly alter zinc excretion despite large increases in urinary sodium excretion and urine flow. In dogs receiving zinc-65, ultrafilterability did not alter throughout the experiments. Glucagon increased zinc-65 clearance by 37 to 75 percent, with clearance of ultrafilterable zinc from 3.8 to 1.3ml/minute. The authors conclude that plasma glucagon, elevated over its physiological range, acutely increases urinary zinc excretion. Altered zinc excretion is probably related to changes in the glomerular filtration rate.
Links with this icon indicate that you are leaving the CDC website.
The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website.
Linking to a non-federal website does not constitute an endorsement by CDC or any of its employees of the sponsors or the information and products presented on the website.
You will be subject to the destination website's privacy policy when you follow the link.
CDC is not responsible for Section 508 compliance (accessibility) on other federal or private website.
For more information on CDC's web notification policies, see Website Disclaimers.
CDC.gov Privacy Settings
We take your privacy seriously. You can review and change the way we collect information below.
These cookies allow us to count visits and traffic sources so we can measure and improve the performance of our site. They help us to know which pages are the most and least popular and see how visitors move around the site. All information these cookies collect is aggregated and therefore anonymous. If you do not allow these cookies we will not know when you have visited our site, and will not be able to monitor its performance.
Cookies used to make website functionality more relevant to you. These cookies perform functions like remembering presentation options or choices and, in some cases, delivery of web content that based on self-identified area of interests.
Cookies used to track the effectiveness of CDC public health campaigns through clickthrough data.
Cookies used to enable you to share pages and content that you find interesting on CDC.gov through third party social networking and other websites. These cookies may also be used for advertising purposes by these third parties.
Thank you for taking the time to confirm your preferences. If you need to go back and make any changes, you can always do so by going to our Privacy Policy page.