NIOSHTIC-2 Publications Search

Mutagenicity of 13 NIOSH priority compounds.

Authors
Schuler RL; Niemeier RW; McGregor DB
Source
Cincinnati, OH: U.S. Department of Health, Education, and Welfare, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, Contract 210-78-0026, 1982 Jan; :1-31
Link
NIOSHTIC No.
00155937
Abstract
The mutagenicities of 3-chloropropene (107051) (CPP), cyclohexanone (108941), methyl-bromide (74839), N,N-dimethylacetamide (127195) (DMAA), N-N-dimethylformamide (68122) (DMFA), N- methyldicyclohexylamine (7560830) (MDCHA), 2-nitropropane (79469), butylene-oxide (26249207), bis(2-methoxyethyl)ether (111966) (BMEE), hexachloro-1,3-butadiene (87683) (HCB), 2-methoxyethanol (109864) (MOE), styrene-oxide (96093), and 1,1,2,2-tetrachloroethane (79345) (TCE) were studied. Dominant lethal, sperm morphology, and bone marrow cytology assays were performed after inhalation exposure of rats and mice 7 hours per day for 5 days. Unscheduled DNA synthesis was measured in-vitro in human embryonic intestinal cells treated for 3 hours at eight concentrations that ranged as high as 9,900 micrograms per milliliter (microg/ml) and as low as 50microg/ml. Drosophila recessive lethal testing exposed flies to various concentrations of the 13 compounds for varying amounts of time. CPP, cyclohexanone, methyl-bromide, DMAA, DMFA, MDCHA, and 2- nitropropane induced no genetic damage. BMEE and MOE produced a strong antifertility effect and some genetic toxicity, and styrene- oxide produced a similar effect but no genetic toxicity. Butylene- oxide produced negative results except in the bone marrow cytology assay where results were questionable. HCB also produced a questionable bone marrow cytology result and exerted an unclear influence during the dominant lethal assay. TCE produced borderline results during both the bone marrow cytology and sperm morphology assays.
Keywords
NIOSH-Author; Chemical-analysis; Analytical-instruments; Biological-effects; Toxicology; Tumorigens; Carcinomas; Exposure-levels; Quantitative-analysis
CAS No.
107-05-1; 108-94-1; 74-83-9; 127-19-5; 68-12-2; 7560-83-0; 79-46-9; 26249-20-7; 111-96-6; 87-68-3; 109-86-4; 96-09-3; 79-34-5
Publication Date
19820101
Document Type
Other
Funding Type
Contract
Fiscal Year
1982
Identifying No.
Contract-210-78-0026
NIOSH Division
DBBS
Source Name
National Institute for Occupational Safety and Health
State
OH
Performing Organization
Inveresk Research International Limited, Musselburgh, Scotland
Page last reviewed: May 5, 2020
Content source: National Institute for Occupational Safety and Health Education and Information Division