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Mutagenicity Of 13 NIOSH Priority Compounds.
Schuler-RL; Niemeier-RW; McGregor-DB
NIOSH :31 pages
The mutagenicities of 3-chloropropene (107051) (CPP), cyclohexanone (108941), methyl-bromide (74839), N,N-dimethylacetamide (127195) (DMAA), N-N-dimethylformamide (68122) (DMFA), N- methyldicyclohexylamine (7560830) (MDCHA), 2-nitropropane (79469), butylene-oxide (26249207), bis(2-methoxyethyl)ether (111966) (BMEE), hexachloro-1,3-butadiene (87683) (HCB), 2-methoxyethanol (109864) (MOE), styrene-oxide (96093), and 1,1,2,2-tetrachloroethane (79345) (TCE) were studied. Dominant lethal, sperm morphology, and bone marrow cytology assays were performed after inhalation exposure of rats and mice 7 hours per day for 5 days. Unscheduled DNA synthesis was measured in-vitro in human embryonic intestinal cells treated for 3 hours at eight concentrations that ranged as high as 9,900 micrograms per milliliter (microg/ml) and as low as 50microg/ml. Drosophila recessive lethal testing exposed flies to various concentrations of the 13 compounds for varying amounts of time. CPP, cyclohexanone, methyl-bromide, DMAA, DMFA, MDCHA, and 2- nitropropane induced no genetic damage. BMEE and MOE produced a strong antifertility effect and some genetic toxicity, and styrene- oxide produced a similar effect but no genetic toxicity. Butylene- oxide produced negative results except in the bone marrow cytology assay where results were questionable. HCB also produced a questionable bone marrow cytology result and exerted an unclear influence during the dominant lethal assay. TCE produced borderline results during both the bone marrow cytology and sperm morphology assays.
NIOSH-Author; Chemical-analysis; Analytical-instruments; Biological-effects; Toxicology; Tumorigens; Carcinomas; Exposure-levels; Quantitative-analysis;
107-05-1; 108-94-1; 74-83-9; 127-19-5; 68-12-2; 7560-83-0; 79-46-9; 26249-20-7; 111-96-6; 87-68-3; 109-86-4; 96-09-3; 79-34-5;
Division of Biomedical and Behavioral Science, NIOSH, U.S. Department of Health and Human Services, Cincinnati, Ohio, 31 pages
Page last reviewed: March 11, 2019
Content source: National Institute for Occupational Safety and Health Education and Information Division