Detection of IgE-mediated respiratory sensitization in workers exposed to hexahydrophthalic anhydride.
Moller DR; Gallagher JS; Bernstein DI; Wilcox TG; Burroughs HE; Bernstein IL
J Allergy Clin Immunol 1985 Jun; 75(6):663-672
Twenty seven workers with occupational exposures to hexahydrophthalic-anhydride (85427) (HHPA) were studied to evaluate the nature of their reported respiratory complaints. Workers completed questionnaires on symptoms and family and personal medical histories. Typical worker exposures were examined. Pre and post shift pulmonary function testing was performed. Immunologic evaluation included radioimmunoassays. Work area monitoring revealed HHPA concentrations from 0.1 to 1.3 parts per million (ppm). Seven of the 27 workers reported asthma symptoms; 4 gave clear histories of occupational asthma. Fifteen other workers reported nasal and ocular symptoms. Pulmonary function testing demonstrated no airway obstruction on pre shift testing, no significant decrements in pulmonary function in post shift testing, and no significant change in forced expiratory volume in 1 second performed on the second work day morning. Specific immunoglobulin-E (IgE) to HHPA human serum albumin (HSA) was detected in 44 percent of workers examined. Seven worked in a high HHPA exposure area and the other five were from adjacent work areas. The seven radioallergosorbent (RAST) positive workers from the HHPA area had worked there for an average of 4.2 years while the 14 RAST negative workers from the same area had worked an average of 1.6 years. All four workers with occupational asthma demonstrated high titers of HHPA/HSA specific IgE, ranging from 8.7 to 23.4 percent. Three workers with symptoms of asthma not clearly associated with the workplace did not have significantly elevated specific IgE titers. Solid phase bead radioimmunoassay detected all positive sera. Specific immunoglobulin-G to HHPA/HSA was demonstrated in 11 of 27 workers. The authors conclude that HHPA should be included in the list of phthalyl anhydrides that cause IgE mediated respiratory disease.
NIOSH-Author; Lung-irritants; Health-standards; Exposure-levels; Lung-lesions; Clinical-symptoms; Clinical-diagnosis; Occupational-exposure; Gas-detectors; Exposure-limits; Lung; Industrial-chemicals
Journal of Allergy and Clinical Immunology