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Health hazard evaluation report: HETA-82-257-1571, Manufacturing Chemists, Inc., Indianapolis, Indiana.
Aw-T-C; Stephenson-RL; Smith-AB; Glueck-CJ
Cincinnati, OH: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, HETA 82-257-1571, 1985 Mar; :1-47
Environmental and breathing zone samples were analyzed for zeranol (26538443) at Manufacturing Chemists, Incorporated (SIC-2879, SIC- requested by the State Industrial Hygiene Compliance Section to assist in evaluating the occurrence of breast symptoms, weight gain, and gynecomastia in employees and their children. Questionnaire interviews were conducted with 11 workers (5 males) and 14 comparisons (8 males). Clinical breast examinations were given to the males. Blood samples were analyzed for zeranol metabolites. Breathing zone zeranol concentrations ranged from 4.1 to 1,554 micrograms per cubic meter; dermal samples contained up to 90 milligrams (mg). Wipe samples showed zeranol concentrations up to 14mg per sample. A sample of work clothing routinely laundered at home contained 16mg of zeranol. There is no current Federal standard for zeranol. Exposed workers reported a higher, though statistically insignificant, prevalence of breast symptoms than comparisons. No evidence of distinct subaureolar masses was found in male subjects. No zeranol metabolites were found in blood samples. The authors conclude that workers have a considerable exposure to zeranol which poses a potential health risk. Recommendations include improving engineering controls and not allowing employees to take work clothing home.
NIOSH-Author; NIOSH-Health-Hazard-Evaluation; NIOSH-Technical-Assistance-Report; Hazards-Confirmed; Animal-products; Region-5; Analytical-chemistry; Chromatographic-analysis; Analytical-instruments; Research; HETA-82-257-1571; Author Keywords: Agricultural Chemicals; Livestock Products; Ralgro; Zeranol; Gynecomastia; Anabolic Agent; Estrogen; Growth-Promoter; Zearalenone; Estradiol
Field Studies; Hazard Evaluation and Technical Assistance
NTIS Accession No.
National Institute for Occupational Safety and Health
Page last reviewed: April 12, 2019
Content source: National Institute for Occupational Safety and Health Education and Information Division