Occupationally related cardiovascular diseases are discussed. Heart diseases and cerebrovascular disease cause more deaths in the US than any other category of disease. Some occupational factors are associated with heart diseases; preventing them would be an important health measure. Environmental factors with potential impact on cardiovascular health include exposure to trace elements, carbon-monoxide, noise and radiofrequency, and physical and psychosocial stress. Metals, dusts, and trace elements are implicated in congestive heart failure and other cardiovascular diseases. Carbon-monoxide studies on workers show a variety of effects including increases in angina pectoris in foundry workers and high shift end carboxyhemoglobin saturations among blast furnace workers. Short term exposure to carbon-monoxide (630080) at concentrations within the OSHA limit of 50 parts per million is associated with decreased exercise tolerance and electrocardiographic evidence of myocardial ischemia. Other chemical exposures causing cardiovascular disorders are examined including carbon-disulfide (75150), halogenated hydrocarbons, nitroglycerin (55630), and nitrates. Effects of noise include increases in blood pressure, increases in serum cholesterol, and changes in circulating hormones. Psychosocial stress is examined, showing that adjustments to the conflicting demands of job and family may be important factors in cardiovascular disease risk.