Reproductive and developmental toxicology of selected epoxides.
Kimmel CA; LaBorde JB; Hardin BD
Toxicology and the Newborn, Kacew 1984; :271-287
The toxic effects of four industrial epoxides are reviewed. The proximate form of a number of carcinogens and mutagens is known to be an epoxide metabolite. Epoxides are also proposed as the active form of certain teratogenic agents. Four such oxides are ethylene- oxide (75218), propylene-oxide (75569), butylene-oxide (26249207), and styrene-oxide (96093). Ethylene-oxide is recognized as mutagenic in rats and mice. The compound causes somatic cytogenic damage in humans as a result of occupational exposure. The compound is also teratogenic in in-vivo mammalian systems. Propylene-oxide is clearly mutagenic in several in-vitro bacterial assays. Chromosomal damage is detected following in-vitro propylene-oxide treatment of human lymphocytes. Data indicates the potential for adverse effects of this compound on fertility and survival of the offspring as well as other forms of fetal toxicity. Butylene-oxide is reported as mutagenic in in-vitro Salmonella, Klebsiella, and mammalian all point mutation assays. Butylene-oxide did not produce any significant developmental toxicity in rabbits or rats in inhalation exposure. Styrene-oxide is mutagenic in a series of in-vitro tests utilizing bacterial, yeast, and mammalian cells in culture. Chromosomal aberrations and sister chromatid exchanges are detected in cultures of human lymphocytes. Styrene-oxide is embryotoxic and teratogenic in chick embryo. The compound is maternally toxic to rats and rabbits, but no evidence of teratogenicity is observed. Increased fetal mortality is noted only in rats at 100 parts per million. The authors conclude that all four epoxides warrant restricted exposure and care when handling.
We take your privacy seriously. You can review and change the way we collect information below.
These cookies allow us to count visits and traffic sources so we can measure and improve the performance of our site. They help us to know which pages are the most and least popular and see how visitors move around the site. All information these cookies collect is aggregated and therefore anonymous. If you do not allow these cookies we will not know when you have visited our site, and will not be able to monitor its performance.
Cookies used to make website functionality more relevant to you. These cookies perform functions like remembering presentation options or choices and, in some cases, delivery of web content that based on self-identified area of interests.
Cookies used to track the effectiveness of CDC public health campaigns through clickthrough data.
Cookies used to enable you to share pages and content that you find interesting on CDC.gov through third party social networking and other websites. These cookies may also be used for advertising purposes by these third parties.