Electrocardiographic study of rat fetuses exposed to ethylene glycol monomethyl ether (EGME).
Toraason-M; Stringer-B; Stober-P; Hardin-BD
The effects of ethylene-glycol-monomethyl-ether (109864) (EGME) on heart function were investigated in Sprague-Dawley-rats. Dams were treated by gavage with 0, 25, 50, or 100 milligrams per kilogram (mg/kg) EGME on days 7 through 13 of gestation. On day 20 of gestation, fetuses with placentas attached were removed and examined by electrocardiogram. Placentas were detached from fetuses, which were then weighed and examined for external physical defects and visceral abnormalities. Treatment of pregnant rats with 100mg/kg EGME caused all fetuses to be resorbed early in gestation. Treatment of pregnant rats with 25 or 50mg/kg EGME did not affect their physical appearance or general behavior. There was a dose dependent increase in cardiovascular defects in fetuses exposed to EGME. The most common abnormality was a ventricular septal defect followed by right ductus-arteriosus, both of which were found only in the 50mg/kg group. Abnormal QRS complexes increased on a dose dependent basis. The mean QRS interval was 34 milliseconds in the control and 25mg/kg groups, and 35 milliseconds in the 50mg/kg group. The pattern of QRS complexes and the increased duration indicated intra ventricular conduction delay. The authors conclude that EGME is teratogenic to rats, inducing a variety of heart and major vessel abnormalities.
NIOSH-Author; Medical-research; Animal-studies; Industrial-chemicals; Biological-effects; Solvents; Teratogens; Toxicopathology; Pathomorphology; Cardiac-function
Division of Biomedical and Behavioral Science, NIOSH, U.S. Department of Health and Human Services, Cincinnati, Ohio, 25 pages, 23 references