Cotton Dust Extract (CDE) Bronchoprovocation: Temporal And Functional Patterns In Monkeys.
Moorman-WJ; Clark-JC; Knecht-EA; Biagini-RE; Lynch-DW; Ainsworth-SK
NIOSH 1985 Mar:22 pages
The effect of bronchoprovocation challenge with cotton dust extracts on pulmonary function was studied in monkeys. Sixteen Cynomolgus- monkeys were challenged with 30 breaths of 0.1 gram per milliliter aerosolized cotton dust extracts or saline. Average flow resistance (FR), dynamic compliance (DC), peak expiratory flow rate (PEFR), forced expiratory flow at 25 percent of vital capacity (FEF 25), and forced expiratory volume in 0.5 second (FEV 0.5) were measured immediately before and at hourly intervals up to 4 hours after challenge. Cotton dust extracts significantly elevated FR within 1 hour of challenge. FR values while showing a decreasing trend were still elevated 4 hours after challenge. DC was concomitantly reduced. Significant decreases in PEFR, FEF 25, and FEV 0.5 occurred only after 4 hours. The authors conclude that FR is the most sensitive functional parameter of cotton dust extract induced bronchial response in monkeys. The nature of the FR response is principally related to tissue resistance instead of airway flow resistance. The monkey offers functional responses to cotton dust extracts similar to those seen in humans.
NIOSH-Author; Animal-studies; Biological-effects; Air-sampling; Lung; Pulmonary-congestion; Respiration; Ventilation; Exposure-methods; Biology;
Division of Biomedical and Behavioral Science, NIOSH, U.S. Department of Health and Human Services, Cincinnati, Ohio, 22 pages, 11 references