Behavioral teratology of industrial solvents is reviewed. Because it is difficult to detect behavioral teratogenic effects in human populations, it is imperative that testing of industrial agents for reproductive effects be undertaken in experimental animals, even though the results will not always be predictive of effects in humans. The criteria for evaluating behavioral teratology studies are enumerated. These include using a sufficient number of litters to detect deviations from controls, being able to separate prenatal and postnatal factors, longitudinal evaluation of offspring, having a testing program that evaluates physical growth and maturation, reflex and motor development, sensory function, activity and reactivity, learning and memory abilities and functioning in neurotransmitter systems, and applying appropriate statistical analyses. Studies of the teratogenic effects of benzene (71432) (postnatal exposure), carbon-disulfide (75150), chloroform (67663), 2-ethoxyethanol (110805), formaldehyde (50000), 2-methoxymethanol (109864), methyl-n-butyl-ketone (591786), methylene-chloride (75092), paint thinner (postnatal exposure), perchloroethylene (127184), and tertiary-butanol (75650) are discussed. For each study, the study design, methodology, and deficiencies that are important for a behavioral teratological evaluation of each solvent are indicated.
Division of Biomedical and Behavioral Science, NIOSH, U.S. Department of Health and Human Services, Cincinnati, Ohio, 37 pages, 37 references