Heart Ornithine Decarboxylase Activity In Neonatal Rats Exposed Prenatally To Ethylene Glycol Monomethyl Ether.
Paper Presented at the 69th Annual Meeting of the Federation of American Societies for Experimental Biology, Poster Presentation No. 10592, 1985 Apr:12 pages
Effects of in-utero exposure to ethylene-glycol-monomethyl-ether (109864) (EGME) on heart function were examined in neonatal Sprague- Dawley-rats. Pregnant females received 25 milligrams per kilogram (mg/kg) EGME on days 7 through 13 or days 13 through 19 of gestation. Maternal body weight, litter weight, and neonatal survival were determined. Heart function was assessed by measuring the stimulation of ornithine-decarboxylase (ODC) activity by administration of 10 milliliters/kg isoproterenol (7683592) in 3, 9, 16, and 22 day old rats. EGME treatments did not affect maternal body weight or reproductive outcome. None of the pups had gross physical defects, and heart and body growth of the neonates were similar for the different groups during the first 22 days of life. In 3 day old rats exposed during days 7 through 13 of gestation, ODC activity was 54 percent of that found in controls. ODC activity of rats exposed on days 13 through 19 of gestation was comparable to that of controls. There were no differences among the groups when rats were 9, 16, or 22 days old. All groups responded to isoproterenol, with the greatest relative response occurring in the 22 day old rats. The authors conclude that EGME exposure in early gestation causes a transient decrease in cardiac ODC activity in neonatal rats at the doses administered in this study.
Medical-research; Animal-studies; Industrial-chemicals; Biological-effects; Solvents; Embryotoxicity; Teratogens; Toxicopathology; Cardiac-function; Enzyme-activity;
Paper Presented at the 69th Annual Meeting of the Federation of American Societies for Experimental Biology, Poster Presentation No. 10592, 12 pages, 5 references