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Mucociliary transport and particle clearance in the human tracheobronchial tree.

Yu CP; Hu JP; Leikauf G; Spektor D; Lippmann M

Aerosols in the mining and industrial work environments, Vol. 1, fundamentals and status. Marple VA, Liu BYH, eds. Ann Arbor, MI: Ann Arbor Science, 1983 Jan; 1:177-184

00150766

A compartmental model describing the mucociliary clearance kinetics of inhaled particles was developed for the human tracheobronchial tree. The model was based on the retention of ferric-oxide (1309371) (Fe2O3). Clearance measurements were made for a subject using monodisperse Fe2O3 aerosol with an aerodynamic diameter of 7.6 micrometers and tagged with radioactive technetium. Before aerosol exposure, the subject performed a series of unspecified respiratory mechanical function tests. Then the subject orally inhaled the test aerosol for 1 minute, regulating his own inspiratory flow rate of rate at 13.6 breaths per minute. Thoracic retention was measured by scintillation count 5 minutes after inhalation and at unspecified times throughout the next 8 hours. An additional measurement was taken the following day. Tracheal transport rates were also determined by scintillation counts. An average tracheal transport rate value of 5 millimeters per minute was observed. Mathematical equations were developed that described a model of mucociliary clearance kinetics. Values of mucociliary transport rate, based on the model, predicted that the total time to clear the tracheobronchial region would be about 8 hours, in agreement with experimental results. However, the tracheal transport rate based on the model was larger than the observed value. The authors conclude that the predictions of the model are within the range of observed values and that the transport rate inconsistency is caused by some of the assumptions made for the lung model.

NIOSH-Grant; Medical-research; Mathematical-models; Analytical-methods; Analytical-models; Respirable-dust; Industrial-dusts; Airborne-particles; Lung-function; Quantitative-analysis; Physiological-measurements; Physiology

Engineering Science S U N Y - at Buffalo Dept of Engineering Science Buffalo, N Y 14214

1309-37-1

19830101

Chapter

Marple VA; Liu BYH

215528

Grant

1983

9780250405312

Grant-Number-R01-OH-00923

Aerosols in the mining and industrial work environments, Vol. 1, fundamentals and status

NY

State University of New York at Buffalo, Buffalo, New York