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Health hazard evaluation report: HETA-80-008-1546, BASF Wyandotte Corporation, Rensselaer, New York.
Gordon JE; Taylor P; Hearn S; Halperin W
Cincinnati, OH: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, HETA 80-008-1546, 1985 Jan; :1-31
A health hazard evaluation at BASF Wyandotte Corporation (SIC-2810, SIC-2820, SIC-2880, SIC-2870), Rensselaer, New York was conducted. The evaluation was requested by a union representative because of adverse pregnancy outcomes among workers involved in the manufacture of 3,5-dinitro-N-4N-4-dipropylsulfanilamide (19044883) (oryzalin). All persons employed from January 1, 1972 through December 31, 1980 were identified from company records. Birth, fetal, and death records were obtained from the State of New York. A total of 286 pregnancies occurred to 1,126 employees who had worked at the facility during the study period. Of these, 270 single pregnancies to wives of male workers were classified according to their possible exposure to oryzalin and the outcome of the pregnancy. Fifteen of the pregnancies occurred to wives of workers who were exposed to oryzalin. Of these, three had an adverse outcome; all three had malformations of the heart. Thirty six of the 255 unexposed pregnancies also showed adverse effects. The authors conclude that workers who were involved in manufacturing oryzalin sired offspring having an unusual cluster of birth defects, especially those of the heart. Whether these were the result of occupational exposure cannot be decisively determined. Implementing proper engineering and work practice controls is recommended.
NIOSH-Author; NIOSH-Health-Hazard-Evaluation; NIOSH-Technical-Assistance-Report; Hazards-Unconfirmed; Chemical-manufacturing-industry; Region-2; Pesticides-and-agricultural-chemicals; Reproductive-effects; Disease-incidence; Industrial-chemicals; HETA-80-008-1546; Author Keywords: Industrial Inorganic Chemicals, Cleaning Agents and Cosmetics, Industrial Organic Chemicals, Agricultural Chemicals; Pesticides; Pregnancy
Field Studies; Hazard Evaluation and Technical Assistance
NTIS Accession No.
2810; 2820; 2880; 2870; 281; 284; 286; 287
National Institute for Occupational Safety and Health
Page last reviewed: September 2, 2020
Content source: National Institute for Occupational Safety and Health Education and Information Division