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Effects of alcohol, caffeine and methyl chloride on man.
Putz-Anderson-V; Setzer-JV; Croxton-JS
Psychol Rep 1981 Jan; 48:715-725
The effects of caffeine (58082), ethanol (64175) and methyl-chloride (74873) were examined in humans. Each participant underwent several tests: dual task; time discrimination; visual vigilance; and dual task and time discrimination. Participant pairs were tested in a controlled environment, seated at a desk in front of a remote, computer controlled cathode ray tube. Pure methyl-chloride was administered from a pressurized cylinder. Room concentrations of methyl-chloride were measured by infrared spectrophotometry and gas chromatography. A dose of 0.8 milligram per kilogram (mg/kg) absolute ethanol was administered in the form of a drink. Caffeine was administered in capsule form at 3mg/kg. Alveolar breath samples for both methyl-chloride and ethanol were collected hourly. Venous blood samples were obtained prior to exposure and 90 minutes after exposure. Within 30 minutes after exposure, the average concentration of methyl-chloride was 199 parts per million. Alcohol and caffeine, when administered independently, produced significant changes in performance. The expected improvement due to caffeine was weak in comparison to the effect of alcohol, which produced systematic impairments on almost all of the test indices. When caffeine and ethanol were administered in conjunction with solvent exposure, the combined result was essentially equivalent to the effect of each agent alone. The authors conclude that the effects of caffeine or alcohol are not enhanced by methyl-chloride.
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