The instructor's resource guide for a course on safety in the school science laboratory (developed by the Division of Training and Manpower Development, NIOSH) is presented. The guide consists of administrative guidelines, lesson plans for lectures in the training course, and workshop lesson plans. The administrative guidelines are primarily intended for State Science Supervisors. Secondary audiences include instructors, resource personnel, and other training personnel. The primary audience of the workshop lessons is the teacher trainee. Lecture lesson topics include legal aspects of classroom safety, student involvement in safety programs, eye and face protection, procedures for handling, storing, and disposing of chemical reagents, labeling, biological and animal hazards, ventilation, fire control, laboratory hardware, and recordkeeping. Workshop lesson plans include safety program planning, eye and face protection, labeling of chemicals, and safety equipment. Appendices include a list of audiovisual aids, library resources, a directory of resources, program evaluation, and a form to be used for performing a walkthrough survey of the school science laboratory facility.