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Developmental toxicity of four glycol ethers applied cutaneously to rats.

Hardin BD; Goad PT; Burg JR
Environ Health Perspect 1984 Aug; 57:69-74
The reproductive and developmental toxicity of ethylene-glycol- monoethyl-ether-acetate (111159) (I), ethylene-glycol-monobutyl- ether (111762) (II), and diethylene-glycol-monoethyl-ether (111900) (III) applied cutaneously was studied in rats and compared to that of ethylene-glycol-monoethyl-ether (110805) (IV). A volume of teratogenic (IV) was applied 4 times daily to shaved interscapular skin of pregnant Sprague-Dawley-rats on days 7 to 16 of gestation as a positive control. Rats were treated with water as a negative control. (I), (II), and (III) in amounts approximately equimolar to (IV) at 2.6 millimoles (mmol) per liter were similarly applied to pregnant rats. Maternal body weights were recorded up to day 21 of gestation when dams were killed and uteri removed, weighed, and examined. Fetal body weights were determined and visceral and skeletal malformations noted. The experiment was repeated using (II) at 0.9mmol. Ten of 11 rats given (II) at an equimolar dose died by day 7 of treatment. Toxic signs were not noted in rats given (I), (III), or (IV). At the decreased dose of (II) no toxic signs appeared in dams. Rats given (IV) and (I) had reduced maternal body weight and a significantly higher frequency of totally resorbed litters and increased numbers of dead implants per litter. There was a significantly reduced number of live fetuses per litter in the (IV) and (I) treated groups and body weights of these fetuses were significantly reduced relative to water treated controls. Visceral malformations were significantly increased over the water control group in rats given (IV) or (I). Skeletal variations were significantly increased in (IV) and (I). (II) and (III) at the reduced dose were not associated with embryo or fetal toxicity. The authors conclude that (I), like (IV), can be absorbed through the skin in embryotoxic, fetotoxic, and teratogenic quantities. No developmental toxicity is observed for (III). (II) also penetrates the skin readily and is lethal to dams at an equimolar concentration with (IV).
NIOSH-Author; Industrial-chemicals; Solvents; Reproductive-effects; Animal-studies; Medical-research; Comparative-toxicology; Skin-absorption; Toxicology; Quantitative-analysis; Embryotoxicity
111-15-9; 111-76-2; 111-90-0; 110-80-5
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Journal Article
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Environmental Health Perspectives
Page last reviewed: November 6, 2020
Content source: National Institute for Occupational Safety and Health Education and Information Division