The permeation resistance of 11 different protective garment materials to epichlorohydrin (106898), perchloroethylene (127184), trichloroethylene (79016), and 1,2-dibromoethane (106934) were determined. The 11 materials tested were surgical rubber, butyl- rubber (9010859), polyethylene (9002884), polyvinyl-alcohol (9002895), Saranex laminated Tyvek, neoprene (69028371), milled nitrile, Viton, Viton-SF, Vitrile, and flexed Teflon (9002840). Samples were clamped in the middle of a standard permeation cell for 24 hours or until a steady state permeation rate was achieved. Materials that showed good permeation resistance were tested for reuse by air drying for 24 hours and then retesting for permeation. All materials except Tyvek were soaked in the challenge liquids, and weight and volume changes that occurred at the end of 24 hours were noted. Of the four challenge liquids tested, only epichlorohydrin showed breakthrough with all 11 materials, and this was delayed for more than 8 hours with butyl-rubber. After reuse, breakthrough occurred with the butyl samples in 5 minutes. With perchloroethylene, neither Viton nor Viton-SF (with either fresh or reused samples) nor Vitrile showed breakthrough at 23 degrees-C. All materials but polyvinyl-alcohol and Teflon were permeated by trichloroethylene. No breakthrough was noted with polyvinyl-alcohol in a reuse test or a test at 45 degrees. When challenged with 1,2- dibromoethane, polyvinyl-alcohol, Viton, Viton-SF, and Vitrile exhibited no breakthrough in 24 hours, nor was any breakthrough detected in reuse tests with polyvinyl-alcohol or Viton. There was a moderately good correlation between the weight and volume changes which occurred when the garment materials were soaked in the challenge liquids and the normalized breakthrough times.