NIOSHTIC-2 Publications Search
The Approaches Of NIOSH.
Structural Correlates of Carcinogenesis and Mutagenesis. A Guide to Testing Priorities. Proceedings of the Second FDA Office of Science Summer Symposium, August 31-September 2, 1977, HEW Publication No. FDA-78-1046 1978:223-226
The approaches NIOSH uses in selecting materials for evaluation as carcinogens are described. Human effects are emphasized. NIOSH sets priorities for laboratory research, industrial surveillance, epidemiological studies, and development of criteria documents for new occupational standards. Occupational exposure patterns, chemical and physical properties, biological effects, production trends, and need for new or revised exposure standards are often used in selection criteria. Emphasis is placed on occupational exposure. Steps used to rank priorities are described. NIOSH and OSHA provide most suggestions but other governments agencies also make suggestions. Criteria document subjects are selected 2 to 3 years in advance in order to provide data for setting occupational standards. About 25 percent of the total criteria documents prepared have involved carcinogenic agents. Sources of data reviewed in establishing priorities include publications, surveys by industrial hygienists, and exposure effect information surveys. There is often a lack of data on human exposure. Animal tests must be used. In many cases the animal exposure studies use routes of exposure which are different than that experienced in the workplace, making it difficult to extrapolate the data. The author suggests that more animal studies use inhalation as the route of administration since it simulates the likely exposure route of a worker.
Environmental-exposure; Toxicology; Environmental-contamination; Carcinogenesis; Hazards; Mutagenesis; Genetics; Hazardous-materials; Proteins; Enzymes; Carcinogens;
Structural Correlates of Carcinogenesis and Mutagenesis. A Guide to Testing Priorities. Proceedings of the Second FDA Office of Science Summer Symposium, August 31-September 2, 1977, HEW Publication No. FDA-78-1046
Page last reviewed: April 12, 2019
Content source: National Institute for Occupational Safety and Health Education and Information Division