Comparative inhalation teratogenicity of four glycol ether solvents and an amino derivative in rats.
Nelson BK; Setzer JV; Brightwell WS; Mathinos PR; Kuczuk MH; Weaver TE; Goad PT
Environ Health Perspect 1984 Aug; 57:261-271
The teratogenicity of inhaled glycol ether solvents and 2- methylaminoethanol (109831) was compared in rats. Pregnant Sprague- Dawley-rats were exposed on gestation days 7 through 15 for 7 hours a day to concentrations not considered toxic to dams of roughly 50, 100 or 200 parts per million (ppm) methoxyethanol (109864), 150 or 200ppm butoxyethanol (111762), 130, 190 or 600ppm ethoxyethyl- acetate (1608726), 100ppm 2-ethoxyethanol (110805) or 150ppm 2- methylaminoethanol. Dams were killed on day 20 and fetuses and resorption sites examined. Neither 2-ethoxyethanol nor 2- methylaminoethanol was embryotoxic. At 200ppm 2-methoxyethanol was highly embryotoxic, producing complete resorptions. At 100 and 50ppm it caused increased resorption, reduced fetal weight and skeletal and cardiovascular defects. At 600ppm 2-ethoxyethyl- acetate induced complete resorption of litters while 390ppm reduced fetal weight and caused skeletal and cardiovascular defects. Only one defect was seen at 130ppm. There were signs of slight maternal toxicity at 200ppm 2-butoxyethanol but no congenital defects resulted at either concentration. The authors conclude that the shorter alkyl chain glycol ethers are more embryotoxic than those with longer chains. The lack of teratogenicity of 2- methylaminoethanol points to a relatively strict structural requirement to produce embryotoxic effects.
NIOSH-Author; Inhalants; Organic-chemicals; Teratogens; Industrial-chemicals; Occupational-exposure; Airborne-dusts; Teratogenesis; Airborne-particles; Monitoring-systems; Monitors; Teratology
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Environmental Health Perspectives