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Industrial Hygiene Characterization Of Commercial Applications Of Genetic Engineering And Biotechnology.

Elliott-LJ; Carson-G; Pauker-S; West-D; Wallingford-K; Greife-A

NIOSH 1983 Sep:41 pages

00145208

Walkthrough surveys of six companies involved in research and development of recombinant DNA techniques applicable to fermentation processes (SIC-7391) were conducted. Engineering controls at the sites included general and local ventilation systems, gas filtration, waste products control, biological safety cabinets, access barriers, and room surfaces that met National Institutes of Health guidelines for working with contaminants. Five companies regularly tested and certified biological safety cabinets and walking hoods, and monitored the autoclaves. Four companies had guidelines for safe work practices and detailed plans for emergencies and laboratory accidents. Three facilities had industrial hygiene programs. All facilities had medical programs, but these varied in objectives, essential elements, and application. The authors note that the companies that were new to the field of fermentation technology were less sophisticated in their approach to occupational health and safety than the more experienced companies. Recommendations include: establishing medical surveillance programs with preemployment and periodic medical examinations and a serological monitoring system; implementing a systematic preventive maintenance system for agitator seals; using control and pressure relief values; installing equipment safeguards; and establishing a registry of all work employed in recombinant DNA processes.

NIOSH-Contract; Biological-effects; Biological-factors; Biological-monitoring; Occupational-exposure; Workplace-studies; Microbiology; Safety-equipment; Accident-prevention; Genetic-engineering; Laboratory-safety; Contract-210-79-0013;

19830901

Contract;

1983

PB85-222875

A04

Contract-210-79-0013

DSHEFS;

7391;

Division of Surveillance, Hazard Evaluations and Field Studies, NIOSH, U.S. Department of Health and Human Services, Cincinnati, Ohio

OH;