Reproductive Outcomes In Wives Of Lead Exposed Workers.
Selevan-SG; Hornung-R; Kissling-GE; Cottrill-C; Leffingwell-SG
NIOSH 1984 Dec:44 pages
A survey of reproductive outcomes in wives of workers exposed to lead (7439921) was conducted. The cohort consisted of the current wives of 376 married male employees of a lead battery (SIC-3691) manufacturer. Pregnancy data was obtained through interviews. Work histories and blood lead concentrations were obtained from company records. Lead exposures were classified as low (25 to 40 micrograms lead per deciliter (microg/dl) of blood), medium (41 to 60microg/dl), high (60microg/dl) or unexposed (less than 25microg/dl). Odds ratios (OR) of fetal loss risk were calculated from the pattern of fetal loss. OR values (adjusted only for maternal age and prior fetal loss) were: 1.5 for the low exposure group, 1.1 for medium exposure, and 0.9 for high exposure. When separated into females who smoked or did not smoke during pregnancy, the OR values were: low exposure nonsmokers, 0.64 and smokers, 6.82; medium exposure nonsmokers, 0.75 and smokers, 1.92; and high exposure nonsmokers, 0.46 and smokers, 2.29. The authors conclude that elevated OR values for fetal loss with paternal lead exposure are observed in females who smoke during pregnancy. The observed inverse dose response pattern could reflect a shift in outcome with increasing lead exposure.
NIOSH-Author; Fertility; Toxicology; Reproductive-system; Reproductive-effects; Fertilizer-industry; Blood-plasma; Blood-samples; Reproduction; Toxicopathology;
NTIS Accession No.
NIOSH, U.S. Department of Health and Human Services, Cincinnati, Ohio, 44 pages, 48 references