Neurobehavioral assessment of chronic low-level methyl bromide exposure in the rabbit.
Russo-JM; Anger-WK; Setzer-JV; Brightwell-WS
J Toxicol Environ Health 1984 Jan; 14(2-3):247-255
Neurobehavioral effects of methyl-bromide (74839) were studied in adult male New-Zealand-white-rabbits. Six rabbits were exposed via inhalation to 27 parts per million methyl-bromide over a period of 8 months, for a total exposure duration of 900 hours. Two control rabbits breathed filtered room air. Biweekly neurobehavioral tests examined the latency rates of the sciatic and ulnar nerves and the amplitude of the eye blink reflex of the orbicularis oculi muscle. Body weights were measured, and feeding and grooming behaviors were observed. Mean latency rates of the sciatic and ulnar nerves of the exposed animals failed to exhibit the anticipated decline characteristic of peripheral nervous system impairment produced by methyl-bromide. Results of eye blink reflex testing also failed to reveal reliable differences that could be attributed to the exposures. Rabbits in the exposed group gained steadily in weight. Control animals also gained weight. No systematic changes in feeding or grooming behaviors were observed. The authors conclude that neurological impairment is not a prominent feature of chronic exposure to low concentrations of methyl-bromide.
NIOSH-Author; Medical-research; Animal-studies; Quantitative-analysis; Neurotoxic-effects; Behavioral-testing; Neurophysiological-effects; Toxic-vapors; Toxicology; Nerve-function; Biological-effects; Industrial-chemicals
Journal of Toxicology and Environmental Health