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Carcinogenic Potential Of Condensed Pyrolysis Effluents From Iron Foundry Casting Operations, Volume V.
Shellenberger TE; Garner FM; Plankenhorn LJ
NIOSH 1984 Oct:211 pages
Data tabulations for a carcinogenesis bioassay of condensed effluents from iron foundry casting operations that used hamsters as the test species are presented. In that study, Syrian-golden- hamsters were administered effluents from shell sand, green sand, furan (110009), or urethane (51796) casting molds once a week for 18 weeks by intratracheal instillation. The concentrations were 5 or 10 milligrams (mg) effluent in 0.2 milliliter of distilled water, except for the effluents from the urethane mold, which were administered in amounts of 2.5 or 5.0mg. Benzo(a)pyrene (50328) plus ferric-oxide (1309371) and ferric-oxide alone were administered as positive controls. The animals were maintained until 98 percent mortality occurred or until week 103 in the case of females or week 117 in the case of males. None of the effluents were found to be carcinogenic at the concentrations used. The histopathological results for each individual animals were tabulated. A tumor inventory for each animal was also constructed.
NIOSH-Contract; Lung-fibrosis; Iron-working-industry; Data-processing; Iron-oxide-fumes; Equipment-design; Pharmacodynamics; Quantitative-analysis; Pyrolysis; Toxicology; Contract-210-78-0033;
110-00-9; 51-79-6; 50-32-8; 1309-37-1;
NTIS Accession No.
Experimental Toxicology Branch, Division of Biomedical and Behavioral Science, NIOSH, U.S. Department of Health and Human Services, Cincinnati, Ohio
Page last reviewed: November 6, 2020
Content source: National Institute for Occupational Safety and Health Education and Information Division