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Carcinogenic Potential Of Condensed Pyrolysis Effluents From Iron Foundry Casting Operations, Volume IV.
Shellenberger TE; Garner FM; Plankenhorn LJ
NIOSH 1984 Oct:185 pages
Data tabulations for a carcinogenic bioassay of condensed effluents from iron foundry casting operations that used hamsters as the test species are presented. In that study, Syrian-golden-hamsters were administered effluents from shell sand, green sand, furan (110009), or urethane (51796) casting molds by intratracheal instillation once a week for 18 weeks. The concentrations were 5 or 10 milligrams (mg) effluent in 0.2 milliliter distilled water, except for effluents from the urethane mold which were administered in amounts of 2.5 or 5.0mg. The animals were maintained until 98 percent mortality occurred or until week 103 or 117. None of the effluents were found to be carcinogenic at the concentrations used. An individual mortality inventory for each animal was calculated. Data for a survival analysis using the Kaplan Meier product limit method was tabulated. Data tables of individual and mean body weights of males for weeks 1 through 111 and females for weeks 11 through 102 were prepared. Data for the statistical analysis of body weight changes of males and females were also tabulated.
NIOSH-Contract; Pharmacodynamics; Lung-fibrosis; Data-processing; Iron-oxide-fumes; Toxicology; Equipment-design; Quantitative-analysis; Iron-working-industry; Pyrolysis; Contract-210-78-0033;
NTIS Accession No.
Experimental Toxicology Branch, Division of Biomedical and Behavioral Science, NIOSH, U.S. Department of Health and Human Services, Cincinnati, Ohio
Page last reviewed: November 6, 2020
Content source: National Institute for Occupational Safety and Health Education and Information Division