Carcinogenic Potential Of Condensed Pyrolysis Effluents From Iron Foundry Casting Operations, Volume I.
Shellenberger-TE; Garner-FM; Plankenhorn-LJ
NIOSH 1984 Oct:98 pages
A carcinogenesis bioassay of condensed pyrolysis effluents from iron foundry casting operations using hamsters was conducted. Syrian- golden-hamsters were administered effluents from shell sand, green sand, furan (110009) or urethane (51796) casting molds intratracheally weekly for 18 weeks. Concentrations were 5 or 10 milligrams (mg) per 0.2 milliliter distilled water except for effluents from the urethane mold which were administered in amounts of 2.5 or 5.0mg. Positive controls were given 3.0mg benzo(a)pyrene (50328) plus 3.0mg ferric-oxide (1309371) or 3.0mg ferric-oxide. The animals were maintained until 98 percent mortality occurred or up to 103 weeks in the case of females or 117 weeks in the case of males. None of the effluents induced a significant carcinogenic response. Comparable numbers of respiratory tract tumors occurred in effluent treated and vehicle controls. Malignant lung tumors occurred with an incidence of 54 to 64 percent in the positive controls. Alveolar and bronchiolar cell hyperplasia was round in all effluent treated and control animals. Nonrespiratory tract tumors occurred sporadically in all treated and control animals. The authors conclude that foundry mold effluents are not carcinogenic in hamsters at the concentrations used. The doses may have been too low, however, to induce a carcinogenic response.
NIOSH-Contract; Epidemiology; Vapors; Gases; Lung-fibrosis; Lung; Lung-cancer; Pyrolysis; Histology; Histopathology; Contract-210-78-0033;
110-00-9; 51-79-6; 50-32-8; 1309-37-1;
NTIS Accession No.
Experimental Toxicology Branch, Division of Biomedical and Behavioral Science, NIOSH, U.S. Department of Health and Human Services, Cincinnati, Ohio