Occupational diseases of the lung.
Green-FH; Tucker-IH; Vallyathan-V
Lab Med 1983 Feb; 14(2):103-112
Occupational diseases of the lung are reviewed. The role of occupational history and environmental sampling in analyses of lung diseases is discussed. Medicolegal aspects of occupational lung disease are considered. Analytical techniques available for investigating suspected occupational lung diseases are reviewed. There are two basic approaches for analytical studies of lung tissue: destructive and nondestructive. The destructive approach involves extracting material, such as minerals and particles, from the tissues. The nondestructive approach involves in-situ analysis of particulates of particles within tissue sections. The destructive approach is best suited for quantitative bulk analysis. Disadvantages of the destructive approach include the inability to correlate the analytical results with morphologic features and the relatively large samples required. Advantages of the nondestructive approach include the ability to correlate the analytical findings with morphologic changes and the ability to use small samples. The use of electron and light microscopy in analyses of lung tissue is discussed. Many cases of pneumoconiosis can be diagnosed by light microscopy. The combination of morphological studies, elemental analyses, and crystallographic studies is usually sufficient to identify most mineral and metal dusts responsible for causing pneumoconiosis. Polarizing light microscopy can be used to diagnose organic dust pneumoconiosis.
Medical-research; Humans; Employee-exposure; Occupational-exposure; Industrial-medicine; Occupational-medicine; Occupational-respiratory-disease; Analytical-methods; Microscopic-analysis; Pathology; Diagnostic-techniques