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Health hazard evaluation report: HETA-83-019-1562, Berlex Labs., Wayne, New Jersey.

Authors
Igliewicz-R; Schmidt-M; Gann-P
Source
Cincinnati, OH: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, HETA 83-019-1562, 1985 Sep; :1-45
NIOSHTIC No.
00143619
Abstract
Breathing zone samples were analyzed for quinidine (56542) at Berlex Laboratories (SIC-2834), Wayne, New Jersey in January, February, and June through August, 1983. The evaluation was requested by the local union to investigate work related skin rashes and respiratory symptoms among employees involved in producing quinidine-gluconate (7054253). Questionnaire interviews were conducted with 47 employees in April, 1984. Medical examinations including serum immunology and skin prick tests were also performed. Airborne quinidine concentrations ranged from 0.2 milligram per cubic meter (mg/m3) in the packaging area to 5.0mg/m3 in the manufacturing area. There is no federal standard for quinidine. Seventy percent of the employees reported respiratory and skin symptoms such as rashes, stuffy nose, red puffed eyes, chest tightness, and wheezing. Nineteen percent of the employees had allergic contact dermatitis. The results of the immunological and skin prick tests were negative. The authors conclude that a health hazard due to exposure to quinidine powder exists. The primary cause of the symptoms appears to be an irritant effect from exposure to the powder. Recommendations include reducing exposures with engineering controls and work practices and developing a personal air sampling protocol.
Keywords
NIOSH-Author; NIOSH-Health-Hazard-Evaluation; NIOSH-Technical-Assistance-Report; Hazards-Confirmed; Chemical-processing; Region-2; Health-hazards; Respiratory-irritants; Skin-exposure; HETA-83-019-1562; Author Keywords: Pharmaceutical Preparations; Pharmaceutical Industry; quinidine; skin sensitivity; mucous membrane irritation; allergy
CAS No.
56-54-2; 7054-25-3
Publication Date
19850901
Document Type
Field Studies; Hazard Evaluation and Technical Assistance
Fiscal Year
1985
NTIS Accession No.
PB86-206075
NTIS Price
A04
Identifying No.
HETA-83-019-1562
NIOSH Division
DSHEFS
SIC Code
2834
Source Name
National Institute for Occupational Safety and Health
State
NJ; OH
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