Evaluation of arsenic metabolites for prenatal effects in the hamster.
Hood-RD; Harrison-WP; Vedel-GC
Bull Environ Contam Toxicol 1982 Dec; 29(6):679-687
The fetal toxicity and teratogenicity of methylated arsenicals were investigated in hamsters. Pregnant female golden-Syrian-hamsters were injected intraperitoneally with a single dose of 500 milligrams per kilogram (mg/kg) disodium-methanearsonate (144218) (DSMA) or 900mg/kg sodium-cacodylate (124652) (NaCA) on one day each of gestation days 8 through 12. Animals were killed on gestation day 15, their livers were weighed, and uterine contents were examined. Neither treatment resulted in altered maternal liver/body weight ratios. NaCA produced its greatest effects on day 9, with 70 percent of litters totally resorbed, 94.8 percent prenatal mortality, and 100 percent of fetuses grossly malformed. Gross malformation, observed in fetuses from all NaCA treatment groups except day 12, included cleft palate, cleft lip, micromelia, syndactyly, exencephaly, and talipes. Fused ribs were detected in the day 8, 9, and 10 NaCA groups. DSMA produced its greatest effects on day 12 with one litter totally resorbed, a prenatal mortality of 20.5 percent, and one fetus grossly malformed. Treatment on days 9, 10, or 12 was followed by fetal stunting. Only three cases of gross malformations were seen: exencephaly; lateral cleft lips; and a short muzzle. The authors conclude that methylation of arsenic greatly reduces its toxicity to adult animals. Both monomethylated and dimethylated arsenicals exhibit less toxicity to the hamster conceptus than would be expected for inorganic arsenic.
NIOSH-Publication; NIOSH-Grant; Heavy-metal-poisoning; Animal-studies; Embryotoxicity; Medical-research; Reproductive-hazards; Biological-effects; Teratogens; Toxicology; Comparative-toxicology;
Biology University of Alabama Post Office Box 1927 University, Ala 35486
Reproductive System Disorders
Bulletin of Environmental Contamination and Toxicology
University of Alabama IN University, University, Alabama