Toxicity tests on post office cancelling ink 1882-17.
Key-MM; Gellin-GA; Perone-YB; Wagner-WD; Groth-DH; Morrill-EE Jr.
U.S. Department of Health, Education, and Welfare, Public Health Service, National Center for Urban and Industrial Health, report no. SR-25, 1968 Apr; :1-11
The toxicity of an ink used by the US Post Office was studied in humans, rats, rabbits, and guinea-pigs. The composition of the ink was determined. Persons involved in developing the ink were examined. Eye irritation tests were performed on albino-rats. Male rats were used for acute oral toxicity tests. Male albino-rabbits were used for acute dermal toxicity and primary dermal irritation tests. Skin sensitization tests were performed on male albino- guinea-pigs. Patch tests and phototoxicity tests were performed on human volunteers. The composition of the ink in percent by weight was as follows: varnish-120-RDE, 30; carbon-black, 10; diethylene- glycol-monobutyl-ether (112345) (DGME), 50; and isopropanol (67630), 10. The composition of varnish-120-RDE in percent by weight was as follows: 1120-maleic-resin, 40; 70-phthalic-anhydride-soya-alkyd, 15; diethylene-glycol-monomethyl-ether (111773), 25; and DGME, 20. Formulators of the ink showed no signs of adverse skin effects. No positive reactions were observed in the eye irritation tests. No ink related pathology was seen in rats in oral toxicity studies. Acute dermal tests produced negative results. Primary skin irritation and skin sensitization tests were all negative. Patch and phototoxicity tests on humans produced no positive cases. The authors conclude that this ink does not present a health hazard when used for intended applications.
Animal-studies; Irritants; Dermatology; Biological-effects; Physiological-response; Skin-sensitivity; Physiological-response; Toxicology; Biological-factors
112-34-5; 67-63-0; 111-77-3
National Center for Urban and Industrial Health