Nationwide surveillance of angiosarcoma of the liver.
Heath-CW Jr.; Key-MM
Arch Environ Health 1974 Jun; 28(6):360-360
Establishment of a surveillance registry for cases of angiosarcoma of the liver in the United States was reported. This was in response to the discovery that cases of angiosarcoma may have developed from vinyl-chloride (75014) (VC) exposure. It was estimated that no more than 15 to 25 cases occurred yearly in the entire United States. Four cases of angiosarcoma were diagnosed since 1968 in workers at a single polyvinyl-chloride (9002862) production factory. Three additional cases had also been reported from the same factory and two cases from other polyvinyl-chloride facilities. All four of the original patients were employed for at least 14 years in various phases of the VC polymerization process. Each worker showed evidence of hepatic fibrosis in the absence of heavy alcohol uptake, prior hepatitis, or exposure to hepatotoxic agents outside the work environment. The authors conclude that the national surveillance registry is a valid part of an effort to define a precise relationship between hepatic angiosarcoma and VC exposure. Physicians who have patients with this diagnosis are urged to contact the Center for Disease Control.
NIOSH-Author; Medical-research; Medical-monitoring; Liver-disorders; Poisons; Fumes; Industrial-chemicals; Occupational-exposure; Safety-research
Archives of Environmental Health