Endotoxins and acute pulmonary function changes during cotton dust exposures.
Olenchock-SA; Castellan-PM; Cocke-JP; Rodak-DJ; Hankinson-JL; Mull-JC
Proceedings of the Seventh Cotton Dust Research Conference, beltwide cotton production research conferences, January 3-4, 1983, San Antonio, Texas. Wakelyn PJ, Jacobs RR, eds. Memphis, TN: The National Cotton Council of America, 1983 Jan; :2 pages
The acute pulmonary function effects of endotoxins during cotton dust exposure were investigated in human subjects. Vertical elutriators were operated in rooms containing airborne cotton dust generated during carding operations. A total of 61 human subjects were assigned to one of two subgroups. Each subgroup was assigned to one of two identical rooms for 6 hour exposures to dust from various cottons and to clean air for comparison exposures. At least 2 days without dust exposure intervened between exposures to dust. Forced expiratory volume (FEV) was measured before and after each exposure period, and changes in pulmonary function were calculated. For the series of exposures to washed cottons, 55 subjects were present for all dust exposures and their results were analyzed. For the series of exposures to cottons of various grades from different growing regions, 56 subjects were exposed and results were analyzed. Statistical analysis of pulmonary data was performed. No endotoxins were detected on filters used on days when subjects were exposed to clean air only. Endotoxin content of airborne dust from carded cottons grown in different geographic locations revealed marked differences. Dust from cotton grown in Texas contained the greatest concentration of endotoxins. For the eight cottons of various grades from different growing locations, a linear correlation was determined between acute pulmonary function decrements and both concentrations of gravimetric elutriated dust and elutriated endotoxins. The authors conclude that water washing of bulk cotton before carding is an effective method of reducing the endotoxin content of airborne dust as well as pulmonary function effect.
Respiratory-gas-analysis; Dust-analysis; Control-methods; Lung-irritants; Comparative-toxicology; Medical-research; Cotton-dusts; Work-environment; Airborne-fibers;
Proceedings of the Seventh Cotton Dust Research Conference, beltwide cotton production research conferences, January 3-4, 1983, San Antonio, Texas