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Arch Pathol Lab Med 1982 Oct; 106(11):541-596
Pathology of asbestos (1332214) associated diseases is evaluated. Historically, asbestos has been used since ancient times. Data indicates that asbestosis was recognized as a disease in 1867. Asbestos in the United States has been in wide use since 1930. Asbestos is used to insulate electrical and heat generating equipment, in building construction, automobile brakes, and in yarns and fabrics. Asbestos refers to a family of naturally occurring, flexible, fibrous hydrous silicate minerals. Two forms of asbestos fibers are found in the lungs: uncoated fibers and asbestos bodies. Longterm exposure to asbestos may result in disease of the pleura or the pulmonary parenchyma. Plaques are considered one of the pathologic and radiologic characteristics of exposure. All commercial types of asbestos induce plaques. Asbestosis is pulmonary fibrosis caused by accumulation of airborne asbestos in the lungs. It is a chronic and progressive disease. Postmortem studies, lung biopsy, and sputum and lavage examination are methods for pathologic determination. A grading system has been developed intended for semiquantitative estimation of the degree of asbestosis. The schema is based on severity of lesions and extent of tissue involvement. Evaluation of a grading system should be done by many pathologists from different backgrounds.
NIOSH-Author; Disease-incidence; Exposure-levels; Pathogenesis; Lung-irritants; Biological-effects; Pulmonary-system-disorders; Disease-prevention; Physiological-response; Biological-factors
Issue of Publication
Archives of Pathology and Laboratory Medicine
Page last reviewed: April 12, 2019
Content source: National Institute for Occupational Safety and Health Education and Information Division