Occupational risks of pesticide exposure for females. Terminal progress report.
Louisiana State Univ Med Ctr, New Orleans Louisiana, 1982 Jan; :1-13
The effects of pesticides on the female reproductive system were studied in chick embryos and mice. Carbaryl (63252) was administered to chick embryos in doses of 1.0 to 10.0 milligrams (mg) for 5 or 12 days. When exposed for 12 days, carbaryl became increasingly embryotoxic and abnormalities such as subcutaneous edema and defects in the hind limbs were observed. Female mice were given 50mg per kilogram (kg) DDT (50293) orally once a week for 4 weeks. They were then treated with gonadotropins. Exposed mice did not ovulate in response to the gonadotropins. In acute experiments, virgin female mice were administered 10 to 300mg/kg DDT daily for 5 days. They were then treated with exogenous gonadotropins and ovaries were examined. Only mice receiving 10 or 50mg/kg DDT survived the experiment. A significant reduction in the number of oocytes ovulated in response to the gonadotropins occurred. Mice were treated with malathion (121755) using the same protocol as with DDT. Malathion did not affect the number of eggs ovulated in response to gonadotropins. The author concludes that DDT has a significant effect on the female reproductive system.
NIOSH-Grant; Animal-studies; Pesticides-and-agricultural-chemicals; Reproductive-hazards; Teratogens; Biological-effects; Toxicology; Comparative-toxicology; Medical-research
63-25-2; 50-29-3; 121-75-5
Final Grant Report
NTIS Accession No.
Louisiana State Univ Med Ctr, New Orleans Louisiana
Louisiana State University, School of Medicine, Department of Anatomy, New Orleans, Louisiana