Co-Carcinogenicity Of Foundry Particulates Silica And Silica Sand Substitutes, Volume 2, Final Report.
NIOSH 1984 Mar:166 pages
The carcinogenicity of silica (14808607) and silica sand substitutes in male Syrian-Golden-hamsters is reviewed. Hamsters were administered silica sand and 10 silica sand substitutes alone or with benzo(a)pyrene (50328) (BP) by intratracheal instillation weekly for 15 weeks. After a total of 92 weeks, instillation of silica and silica sand substitutes alone did not induce malignant tumors in the respiratory tract. When given in combination with BP, the silica sand and substitutes caused malignant tumors in all parts of the respiratory tract. The only exception to this finding was seen with an aluminum (7429905) containing substitute. The tumors were classified as adenocarcinomas, squamous cell carcinomas, adenosquamous carcinomas, carcinomas, and sarcomas of various types. Benign tumors, mostly epithelial polyps, were found most frequently in the larynx and trachea. Analyses of the animal feed, Rodent Laboratory Chow, tabulations of clinical observations, and life table analyses of the animals that had tumors in the larynx, trachea, or lung are presented.
NIOSH-Contract; Industrial-exposures; Animal-studies; Carcinogenicity; Airborne-particles; Foundry-sands; Silica-dusts; Tumorigens; Histopathology; Mortality-data; Contract-210-79-0036;
14808-60-7; 50-32-8; 7429-90-5;
NTIS Accession No.
Division of Biomedical and Behavioral Science, NIOSH, U.S. Department of Health and Human Services, Cincinnati, Ohio