Final Report. Lung Mechanics In Occupational Respiratory Disease.
The mechanics of lung functioning in occupational respiratory diseases were studied in laboratory animals. Results of experiments involving gas formation in isolated lungs were summarized. Gas was found to be trapped in isolated lungs as they were inflated from the gas free state. Meniscus formation in the airways during lung deflation at low volumes was primarily responsible for the trapped gas. A method was developed to detect meniscus formation in isolated rat lungs. Meniscus formation in the small airways was found to depend primarily on the diameter, length, and fluid surface properties of the airways. The formation of menisci in the airways of various animals with symptoms of respiratory disease were studied. In the early stages of pulmonary edema, excess fluid caused menisci to form in the edematous airways sooner than in normal airways during lung deflation. The author concludes that meniscus formation is an indicator of pulmonary disease that affects the diameter, length, or fluid surface properties of the airways in the peripheral part of the lung.
NIOSH-Author; Animal-studies; Diagnostic-techniques; Industrial-medicine; Occupational-medicine; Lung-disorders; Medical-research; Clinical-symptoms;
NTIS Accession No.
NIOSH, U.S. Department of Health, Education, and Welfare, Cincinnati, Ohio, 2 pages, 8 references